Enterprise Investment Scheme Association director general Sarah Wadham is to step down from her role at the end of March.
Wadham, who has been at the helm of the trade body for three years, will remain on the EISA board.
A spokesman for EISA says it is actively seeking applicants from within and outside the industry to replace Wadham.
The EISA says Wadham will continue to focus on the UK’s enterprise and venture capital sectors as well as continue working on other major projects.
Wadham says: “Serving as EISA director general has been an extremely enjoyable and rewarding experience. The work EISA does is incredibly important and the role of director general seems to grow in scope and scale week by week. I’ve invested a huge amount of time and energy into it since 2013 and I feel now it is time to hand over the reins to fresh hands.
“I am pleased to leave the organisation in a better position than when I became director general in 2013, helped by the collective efforts of EISA’s board and the members. Membership has grown and continues to increase including more members from the regions.”